- Recommended name
- Caribbean Ciguatoxin-1
- Synonyms
- n/a
- Recommended acronym
- C-CTX1
- Abbreviation
Progenitors
- Name
- Gambierdiscus silvae
Vector Species
- Name
- Muraena helena
- Name
- Diplodus vulgaris
- Name
- Caranx latus
- Name
- Caranx lugubris
- Name
- Lutjanus griseus
- Name
- Serranidae
- Note
- Pottier et al. 2002 Food Add. Comtam. did not specify the genus/species of "a grouper"
- Name
- Sphyraena barracuda
- Name
- Lutjanus cyanopterus
- Name
- Bodianus scrofa
- Name
- Seriola fasciata
- Name
- Pterois volitans
References
- Lewis RJ, Vernoux J-P, Breteton IM, 1998
- Pottier I, Vernoux J-P, Jones A, Lewis RJ, 2002
- Pottier I, Vernoux J-P, Jones A, Lewis RJ, 2002
- Abraham A, Jester ELE, Granade HR, Plakas SM, Dickey RW, 2012
- Kryuchkov F, Robertson A, Miles CO, Mudge EM, Uhlig S, 2020
- Estevez P, Prieto JO, Burlingame A, Gago Martinez A, 2023
- Estevez P, Castro D, Pequeño-Valtierra A, Leao JM, Vilariño O, Diogène J, Gago-Martínez A, 2019
- Estevez P, Sibat M, Leão-Martins JM, Costa PR, Gago-Martínez A, Hess P, 2020
- Mudge EM, Miles CO, Ivanova L, Uhlig S, James KS, Erdner DL, Fæste CK, McCarron P, Robertson A, 2023
- Robertson A, Garcia AC, Flores Quintana HA, Smith TB, Castillo BF, Reale-Munroe K, Gulli JA, Olsen DA, Hooe-Rollman JI, Jester ELE, Klimek BJ, Plakas SM, 2014
- Ramos-Sosa MJ, García-Álvarez N, Sanchez-Henao A, Sergent FS, Padilla D, Estévez P, Caballero MJ, Martín-Barrasa JS, Gago-Martínez A, Diogène J, Real F, 2022
- Structure
-
- Formula
- C62H92O19
- Exact mono-isotopic mass
- 1140.6233
- Molfile
- n/a
- Alternative molfiles
- n/a
- SMILES
- O[C@@H]1C[C@@]2([H])[C@](C[C@@](O[C@@](C=C[C@@](O[C@@](C/C=C\C[C@@](O[C@@](C[C@@](O[C@@](C[C@@](O[C@@](C[C@@](O[C@@](CC[C@](CO)(O)O3)(C)[C@]3([H])CC4)(C)[C@]4([H])O5)([H])[C@]5(C)[C@@H](O)C6)([H])[C@]6([H])O7)([H])[C@]7([H])C[C@@H](C)C8)([H])[C@]8([H])O9)([H])[C@]9(C)[C@H](O)C%10)([H])[C@]%10([H])O%11)([H])[C@]%11([H])/C=C\C%12)([H])[C@]%12([H])O%13)([H])[C@]%13([H])C%14)([H])[C@]%14([H])O2)([H])OCC1
- Alternative SMILES
- n/a
- InChi key
- WFCQOYJANLJDGJ-AWRGGPNBSA-N
- Alternative InChi keys
- n/a
- InChi
- InChI=1S/C62H92O19/c1-32-21-41-45(26-47-49(73-41)28-53(66)61(5)57(77-47)30-59(3)55(79-61)16-15-54-58(2,81-59)18-19-62(67,31-63)80-54)75-50-29-56-60(4,78-51(50)22-32)52(65)27-48-37(76-56)10-7-6-9-34-35(71-48)11-8-12-36-38(69-34)13-14-39-43(70-36)25-46-44(72-39)24-40-42(74-46)23-33(64)17-20-68-40/h6-8,11,13-14,32-57,63-67H,9-10,12,15-31H2,1-5H3/b7-6-,11-8-/t32-,33+,34-,35+,36-,37+,38+,39-,40-,41+,42+,43+,44+,45-,46-,47+,48-,49-,50+,51-,52-,53+,54+,55-,56-,57-,58-,59+,60+,61+,62+/m1/s1
- Alternative InChis
- Spectra available
- True
- Chem files
- chemfiles/C-CTX1.mol chemfiles/C-CTX1.cdx
References
- Certified
- False
- Certified links
-
-
n/a
- Non certified reference material
- Unknown
Chemical analysis
- Research
- True
- Standardized
- False
- Validated
- False
- Official
- n/a
Structure recognition assays
- Research
- True
- Standardized
- False
- Validated
- False
- Official
- n/a
Functional assays
- Research
- True
- Standardized
- False
- Validated
- False
- Official
- n/a
Animal assays
- Research
- Unknown
- Standardized
- Unknown
- Validated
- Unknown
- Official
- n/a
References
- Regulatory status
- Unknown
References
- , None
- There is a difference in regulatory status for CTX1 in USA and EU. While EU regulation states it shiould absent, USA-regulation is only FDA guidance
- Human toxic syndrome(s)
- Ciguatera Poisoning
- Organ system toxicity
- Cardiotoxicity, Neurotoxicity, Gastro-intestinal toxicity
- Risk assessment
- Unknown
- Molecular targets known
- True
- Molecular targets
- Voltage dependent sodium channel (site 5)
- Toxic to aquatic animals
- Unknown
- TEF available
- Unknown
TEF References
- Notes
- C-CTX1 i.p LD50 in 20 g mice is 3.6 μg/kg according to Lewis et al. 1998 https://doi.org/10.1021/ja980389e